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Cytotoxicity-Related Gene Expression and Chromatin Accessibility Define a Subset of CD4+ T Cells That Mark Progression to Type 1 Diabetes.

Diabetes - 1 Mar 2022

Bediaga Naiara G, Garnham Alexandra L, Naselli Gaetano, Bandala-Sanchez Esther, Stone Natalie L, Cobb Joanna, Harbison Jessica E, Wentworth John M, Ziegler Annette-G, Couper Jennifer J, Smyth Gordon K, Harrison Leonard C

Abstract excerpt

Type 1 diabetes in children is heralded by a preclinical phase defined by circulating autoantibodies to pancreatic islet antigens. How islet autoimmunity is initiated and then progresses to clinical diabetes remains poorly understood. Only one study has reported gene expression in specific immune cells of children at risk associated with progression to islet autoimmunity. We analyzed gene expression with RNA...

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Share to Autoimmunity
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Chromatin

Share to Cytotoxicity, Immunologic

Share to Islets of Langerhans

Share to Killer Cells, Natural

Share to Sequence Analysis, RNA

Source

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Identifiers

PMID: 35007320
DOI: 10.2337/db21-0612
PMCID: PMC8893947

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