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Article

Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling.

Journal of autoimmunity - 1 Aug 2010

Elo Laura L, Mykkänen Juha, Nikula Tuomas, Järvenpää Henna, Simell Satu, Aittokallio Tero, Hyöty Heikki, Ilonen Jorma, Veijola Riitta, Simell Tuula, Knip Mikael, Simell Olli, Lahesmaa Riitta

Abstract excerpt

Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing pancreatic beta cells in the islets of Langerhans. Although defects in various T cell subsets have been linked to the disease pathogenesis, mechanisms initiating or enhancing the autoimmunity in prediabetes remain poorly understood. To unravel genes and molecular pathways affected by the diabetes-associated autoimmunity, we...

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Identifiers

PMID: 20356713
DOI: 10.1016/j.jaut.2010.03.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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