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Article

[BIN1 (amphiphysin 2) in the pathogenesis of cognitive impairment].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 1 Jan 2026

Shamakina I Yu, Kokhan V S, Venkova V A, Baronets V Yu, Popov S S, Anokhin P K

Abstract excerpt

As shown by a genome-wide association study (GWAS), the Bridging Integrator 1 (BIN1) gene is the second most important genetic locus associated with Alzheimer's disease risk, after apolipoprotein E (APOE). Amphiphysin 2 (Bin1), encoded by this gene, is an adaptor protein involved in the regulation of synaptic vesicular transport and neurotransmission. In Alzheimer's disease patients, Bin1 protein expression was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41984553
DOI: 10.17116/jnevro202612603145

Genes

BIN1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

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[BIN1 (amphiphysin 2) in the pathogenesis of cognitive impairment].PMID 41984553Read ↗

Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease.Semantic proximity Read ↗

The Mechanistic Role of Bridging Integrator 1 (BIN1) in Alzheimer's Disease.Semantic proximity Read ↗

BIN1 regulates BACE1 intracellular trafficking and amyloid-β productionSemantic proximity Read ↗

Bridging Integrator 1 (BIN1) Protein Expression Increases in the Alzheimer's Disease Brain and Correlates with Neurofibrillary Tangle PathologySemantic proximity Read ↗

New Insights on Bridging Integrator 1 Protein Isoforms as a Risk Increasing Gene in Alzheimer’s DiseaseSemantic proximity Read ↗

Aberrant accrual of BIN1 near Alzheimer’s disease amyloid deposits in transgenic modelsSemantic proximity Read ↗

Amphiphysin 2 (BIN1) in physiology and diseasesSemantic proximity Read ↗

Bridging Integrator 1 (BIN1) Genotypes Mediate Alzheimer's Disease Risk by Altering Neuronal Degeneration.Semantic proximity Read ↗

Amphiphysin-2 (BIN1) functions and defects in cardiac and skeletal muscle.Semantic proximity Read ↗

The bridging integrator 1 Gene rs7561528 polymorphism contributes to Alzheimer's disease susceptibility in East Asian and Caucasian populations.Semantic proximity Read ↗

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memorySemantic proximity Read ↗

Bridging integrator 1 protein loss in Alzheimer’s disease promotes synaptic tau accumulation and disrupts tau releaseSemantic proximity Read ↗

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