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Article

RIN3 mutations impairing binding of the Alzheimer's disease-associated protein BIN1 lead to RAB5 hyperactivation and endosomal pathology.

Science advances - 30 Jan 2026

Maaser-Hecker Anna K, Zellmer Jacob C, Kim Michelle, Bakiasi Grisilda, Maiti Amit K, Curtat Matea P C, Choi Se Hoon, Prokopenko Dmitry, Tanzi Rudolph E, Bhattacharyya Raja

Abstract excerpt

Alzheimer's disease (AD) risk is strongly influenced by genetic variants that converge on pathways regulating endosomal homeostasis. Among these, BIN1 and RIN3 have emerged as susceptibility genes, yet their functional relationship in AD remains largely unknown. Here, we investigated how BIN1 and RIN3 interaction regulates RAB5 activity and endosomal pathology. RIN3 has been shown to bind BIN1, and we previously...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41604486
DOI: 10.1126/sciadv.adx2127
PMCID: PMC12851038

Genes

RIN3
BIN1
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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