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Article

Restriction of extracellular lipids renders pancreatic cancer dependent on autophagy

8 Jan 2022

Abstract excerpt

Abstract Background KRAS is the predominant oncogene mutated in pancreatic ductal adenocarcinoma (PDAC), the fourth cause of cancer-related deaths worldwide. Mutant KRAS-driven tumors are metabolically programmed to support their growth and survival, which can be used to identify metabolic vulnerabilities. In the present study, we aimed to understand the role of extracellularly derived fatty acids in KRAS-driven...

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Share to Autophagy in Disease and Therapy
Share to Cancer, Lipids, and Metabolism
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PMID: 34998392
DOI: 10.1186/s13046-021-02231-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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