Article

Vertical RAS-pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations

2025-02-08

Abstract excerpt

<h4>Background & Aims</h4> Oncogenic KRAS mutations drive metabolic rewiring in pancreatic ductal adenocarcinoma (PDAC). Src-homology 2 domain-containing phosphatase 2 (SHP2) is essential for full KRAS activity and promising dual SHP2/mitogen-activated protein kinase (MAPK) inhibition is currently being tested in clinical trials. Exploitable metabolic adaptations may contribute to an invariably evolving resistanc...

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Literature Corpus work: 8ed4df3a-f8c1-5403-a9ce-9e9dd26e5bc8
DOI: 10.1101/2025.02.03.636222

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