Article
Roles of autophagy and metabolism in pancreatic cancer cell adaptation to environmental challenges.
American journal of physiology. Gastrointestinal and liver physiology - 1 Nov 2017
Maertin Sandrina, Elperin Jason M, Lotshaw Ethan, Sendler Matthias, Speakman Steven D, Takakura Kazuki, Reicher Benjamin M, Mareninova Olga A, Grippo Paul J, Mayerle Julia, Lerch Markus M, Gukovskaya Anna S
Abstract excerpt
Pancreatic ductal adenocarcinoma (PDAC) displays extensive and poorly vascularized desmoplastic stromal reaction, and therefore, pancreatic cancer (PaCa) cells are confronted with nutrient deprivation and hypoxia. Here, we investigate the roles of autophagy and metabolism in PaCa cell adaptation to environmental stresses, amino acid (AA) depletion, and hypoxia. It is known that in healthy cells, basal autophagy...
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