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Article

Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ialpha are required for invadopodia formation in human breast cancer cells.

Cancer science - 1 Jul 2010

Yamaguchi Hideki, Yoshida Shuhei, Muroi Emi, Kawamura Masahiro, Kouchi Zen, Nakamura Yoshikazu, Sakai Ryuichi, Fukami Kiyoko

Abstract excerpt

Invadopodia are ventral cell protrusions formed in invasive cancer cells. Because invadopodia have extracellular matrix (ECM) degradation activity, they are thought to function in cancer invasion. In this study, we examined the roles of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)] and PI(4,5)P(2)-producing enzymes in invadopodia formation in MDA-MB-231 human breast cancer cells. Immunofluorescence analysis...

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Identifiers

PMID: 20426790
DOI: 10.1111/j.1349-7006.2010.01574.x
PMCID: PMC11158062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphatidylinositol 4,5-bisphosphate and PIP5-kinase Ialpha are required for invadopodia formation in human breast cancer cells.PMID 20426790Read ↗

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