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Article

INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer.

Nature communications - 25 May 2021

Rodgers Samuel J, Ooms Lisa M, Oorschot Viola M J, Schittenhelm Ralf B, Nguyen Elizabeth V, Hamila Sabryn A, Rynkiewicz Natalie, Gurung Rajendra, Eramo Matthew J, Sriratana Absorn, Fedele Clare G, Caramia Franco, Loi Sherene, Kerr Genevieve, Abud Helen E, Ramm Georg, Papa Antonella, Ellisdon Andrew M, Daly Roger J, McLean Catriona A, Mitchell Christina A

Abstract excerpt

INPP4B suppresses PI3K/AKT signaling by converting PI(3,4)P2 to PI(3)P and INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is also a reported oncogene in other cancers. How these opposing INPP4B roles relate to PI3K regulation is unclear. We report PIK3CA-mutant ER+ breast cancers exhibit increased INPP4B mRNA and protein expression and INPP4B increased the proliferation and...

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PMID: 34035258
DOI: 10.1038/s41467-021-23241-6
PMCID: PMC8149851

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