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Article

Activating Mutations in PIK3CB Confer Resistance to PI3K Inhibition and Define a Novel Oncogenic Role for p110β.

Cancer research - 1 Mar 2016

Nakanishi Yoshito, Walter Kimberly, Spoerke Jill M, O'Brien Carol, Huw Ling Y, Hampton Garret M, Lackner Mark R

Abstract excerpt

Activation of the PI3K pathway occurs commonly in a wide variety of cancers. Experience with other successful targeted agents suggests that clinical resistance is likely to arise and may reduce the durability of clinical benefit. Here, we sought to understand mechanisms underlying resistance to PI3K inhibition in PTEN-deficient cancers. We generated cell lines resistant to the pan-PI3K inhibitor GDC-0941 from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

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Share to Phosphatidylinositol 3-Kinases

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Source

Identifiers

PMID: 26759240
DOI: 10.1158/0008-5472.CAN-15-2201

Genes

PTEN
PDK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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