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Article

GPCR Signaling Mediates Tumor Metastasis via PI3Kβ

24 Mar 2016

Abstract excerpt

Inappropriate activation of PI3K signaling has been implicated strongly in human cancer. Although studies on the role of PI3K signaling in breast tumorigenesis and progression have focused most intensively on PI3Kα, a role for PI3Kβ has begun to emerge. The PI3Kβ isoform is unique among class IA PI3K enzymes in that it is activated by both receptor tyrosine kinases and G-protein-coupled receptors (GPCR). In...

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PMID: 27013201
DOI: 10.1158/0008-5472.can-15-1675

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