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Article

Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice

5 Jan 2022

Abstract excerpt

The intervertebral disc (IVD) is the largest avascular tissue. Hypoxia-inducible factors (HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease (DDD) is one of the leading causes of disability, and current therapies are ineffective. This study sought to explore the role of HIFs in DDD pathogenesis in mice. The findings of this study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34983922
DOI: 10.1038/s41413-021-00165-x

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