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Article

SHH-dependent knockout of HIF-1 alpha accelerates the degenerative process in mouse intervertebral disc.

International journal of immunopathology and pharmacology - 1 Jan 2000

Wu W J, Zhang X K, Zheng X F, Yang Y H, Jiang S D, Jiang L S

Abstract excerpt

Hypoxia-inducible factor-1alpha (HIF-1 alpha) has been reported to have an important role in the metabolism and synthesis of extracellular matrix of the nucleus pulposus cells (NPCs) and was assumed to be involved in the process of intervertebral disc degeneration. The objective of this study was to investigate the role of HIF-1alpha in disc degeneration in vivo using a conditional HIF-1alpha knockout (KO) mouse...

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Source

Identifiers

PMID: 24067457
DOI: 10.1177/039463201302600304

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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