Article

Hypoxia-inducible Factor-1α protects against Intervertebral Disc Degeneration through Antagonizing Mitochondrial Oxidative Stress.

2022-05-13

Abstract excerpt

Intervertebral disc degeneration (IVDD) demonstrates a gradually increased incidence and has developed into a major health problem worldwide. Nucleus pulposus is characterized by the hypoxic and avascular environment, in which hypoxia inducible factor1α (HIF-1α) has an important role through its participation in extracellular matrix synthesis, energy metabolism, cellular adaptation to stresses and genesis. In this...

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Literature Corpus work: 99d41060-e937-5d65-b324-82a434214b3a
DOI: 10.21203/rs.3.rs-1637390/v1

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