Article
Beta-defensin 1 knockdown ameliorates the characteristics of intervertebral disc degeneration by altering nucleus pulposus and annulus fibrosus cell phenotypes via suppression of the extracellular signal-regulated kinase signaling pathway.
Osteoarthritis and cartilage - 1 May 2025
Wei Chao, Wang Xiaobin, Wu Siwen, Chen Yiyuan, Lai Shunxun, Liu Fubin, Wu Hailin, Lin Renqin, Li Jing
Abstract excerpt
OBJECTIVE: Beta-defensin 1 (DEFB1), is a member of the defensin family involved in inflammation, cell apoptosis and senescence. We hypothesized that DEFB1 is essential for intervertebral disc (IVD) homeostasis. Our objective was to elucidate the roles of DEFB1 in IVD degeneration (IDD). DESIGN: DEFB1 expression in human degenerated and non-degenerated IVD tissues was measured. In the rat coccygeal IDD model,...
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