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Article

Age‐related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration

21 Apr 2017

Abstract excerpt

Aging is a main risk factor for intervertebral disc (IVD) degeneration, the main cause of low back pain. FOXO transcription factors are important regulators of tissue homeostasis and longevity. Here, we determined the expression pattern of FOXO in healthy and degenerated human IVD and the associations with IVD degeneration during mouse aging. FOXO expression was assessed by immunohistochemistry in normal and...

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PMID: 28430387
DOI: 10.1002/jor.23583

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