Article
Decellularized extracellular matrix-based scaffold and hypoxic priming: A promising combination to improve the phenotype of degenerate intervertebral disc cells.
Life sciences - 15 Jul 2022
Penolazzi Letizia, Lambertini Elisabetta, D'Agostino Stefania, Pozzobon Michela, Notarangelo Maria Pina, Greco Pantaleo, De Bonis Pasquale, Nastruzzi Claudio, Piva Roberta
Abstract excerpt
AIMS: The main cause of low back pain is the intervertebral disc (IVD) degeneration. Designing an effective disc regeneration strategy still remains a major challenge, especially for the lack of effective self-healing capacity. Understanding the properties of IVD cells in the degenerate microenvironment could help to develop in situ regeneration strategies. The objective of the present study was to investigate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.