Article
Peanut-allergic subjects and their peanut-tolerant siblings have large differences in peanut-specific IgG that are independent of HLA class II.
Clinical immunology (Orlando, Fla.) - 1 Dec 2010
Dreskin Stephen C, Tripputi Mark T, Aubrey Michael T, Mustafa S Shahzad, Atkins Dan, Leo Harvey L, Song Benjamin, Schlichting Darcy, Talwar Hanna, Wang Qian, Freed Brian M
Abstract excerpt
We enrolled 53 peanut-allergic subjects and 64 peanut-tolerant full siblings, measured peanut-specific IgG and IgE, determined HLA class II at high resolution, and analyzed DRB1 alleles by supertypes. Peanut-specific IgG and IgE were elevated in the peanut-allergic subjects (p<0.0001) but did not stratify with HLA alleles, haplotypes, or supertypes. There were no significant differences in HLA class II between...
Topics
- Adolescent
- Adult
- Aged
- Arachis
- Child
- Child, Preschool
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- HLA-DR Antigens