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Article

Peanut-allergic subjects and their peanut-tolerant siblings have large differences in peanut-specific IgG that are independent of HLA class II.

Clinical immunology (Orlando, Fla.) - 1 Dec 2010

Dreskin Stephen C, Tripputi Mark T, Aubrey Michael T, Mustafa S Shahzad, Atkins Dan, Leo Harvey L, Song Benjamin, Schlichting Darcy, Talwar Hanna, Wang Qian, Freed Brian M

Abstract excerpt

We enrolled 53 peanut-allergic subjects and 64 peanut-tolerant full siblings, measured peanut-specific IgG and IgE, determined HLA class II at high resolution, and analyzed DRB1 alleles by supertypes. Peanut-specific IgG and IgE were elevated in the peanut-allergic subjects (p<0.0001) but did not stratify with HLA alleles, haplotypes, or supertypes. There were no significant differences in HLA class II between...

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Identifiers

PMID: 20850383
DOI: 10.1016/j.clim.2010.08.009
PMCID: PMC2976616

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