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Ara h 2–expressing cucumber mosaic virus–like particle (VLP Peanut) induces in vitro tolerogenic cellular responses in peanut-allergic individuals

1 Jan 2025

Abstract excerpt

BACKGROUND: Peanut allergy (PA) is one of the most prevalent food allergies with a lack of favorable safety/efficacy treatment. A cucumber mosaic virus-like particle expressing peanut allergen component Ara h 2 (VLP Peanut) has been developed as a novel therapeutic approach for PA. OBJECTIVE: We assessed the tolerogenic properties and reactivity of VLP Peanut. METHODS: Whole blood and peripheral blood mononuclear...

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PMID: 39756833
DOI: 10.1016/j.jaci.2024.08.010

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