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Article

New Mechanism of Acyclovir Resistance in Herpes Simplex Virus 1, Which Has a UAG Stop Codon between the First and Second AUG Initiation Codons.

Japanese journal of infectious diseases - 24 Nov 2020

Nguyen Phu Hoang Anh, Yamada Souichi, Shibamura Miho, Inagaki Takuya, Fujii Hikaru, Harada Shizuko, Fukushi Shuetsu, Mizuguchi Masashi, Saijo Masayuki

Abstract excerpt

Morphological changes in the structure of the herpes simplex virus 1 (HSV-1) viral thymidine kinase (vTK) polypeptide usually lead to conferring acyclovir (ACV) resistance. HSV-1 I4-2, in which a UAG stop codon is present at the 8th position between the 1st initiation AUG codon (1st position) and the 2nd initiation AUG codon (46th position) of the HSV-1 vTK gene, showed sensitivity to ACV. In contrast, HSV-1...

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Identifiers

PMID: 32611982
DOI: 10.7883/yoken.JJID.2020.313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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