Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Mutation of the Genes Related to Neurovirulence in HSV-2 Produces an Attenuated Phenotype in Mice.

Viruses - 17 Jul 2020

Liu Lei, Cheng Jishuai, Mou Tangwei, Zhang Ying, Xu Xingli, Zhang Jingjing, Li Xueqi, Feng Xiao, Xu Xiangxiong, Liao Yun, Fan Shengtao, Wang Lichun, Jiang Guorun, Li Qihan

Abstract excerpt

HSV-2 (Herpes simplex virus type 2) is a critical viral agent that mainly causes genital herpes and life-long latent infection in the dorsal root ganglia. Gene modification via CRISPR/Cas9 Clustered regularly interspaced short palindromic repeat sequences/CRISPR associated 9) was used here to construct HSV-2 mutant strains through the deletion of fragments of the RL1 (Repeat Long element 1) and/or LAT...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to Herpes Simplex

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Herpesvirus 2, Human

Share to Mice, Inbred BALB C

Share to Vero Cells

Share to Viral Plaque Assay

Share to Viral Proteins

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 32708847
DOI: 10.3390/v12070770
PMCID: PMC7412103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Mutation of the Genes Related to Neurovirulence in HSV-2 Produces an Attenuated Phenotype in Mice.PMID 32708847Read ↗

Generation and characterization of UL41 null pseudorabies virus variant in vitro and in vivo.Semantic proximity Read ↗

A knockdown of the herpes simplex virus type-1 gene in all-in-one CRISPR vectorsSemantic proximity Read ↗

Potential Application of the CRISPR/Cas9 System against Herpesvirus InfectionsSemantic proximity Read ↗

Herpes simplex virus latency-associated transcript sequence downstream of the promoter influences type-specific reactivation and viral neurotropism.Semantic proximity Read ↗

CLEAR Strategy Inhibited HSV Proliferation Using Viral Vectors Delivered CRISPR-Cas9Semantic proximity Read ↗

Complete and Prolonged Inhibition of Herpes Simplex Virus Type 1 Infection In Vitro by CRISPR/Cas9 and CRISPR/CasX SystemsSemantic proximity Read ↗

Attenuated phenotypes and analysis of a herpes simplex virus 1 strain with partial deletion of the UL7, UL41 and LAT genes.Semantic proximity Read ↗

Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced ReactivationSemantic proximity Read ↗

CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent InfectionsSemantic proximity Read ↗

An acutely and latently expressed herpes simplex virus 2 viral microRNA inhibits expression of ICP34.5, a viral neurovirulence factorSemantic proximity Read ↗

Two Small RNAs Encoded within the First 1.5 Kilobases of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Can Inhibit Productive Infection and Cooperate To Inhibit ApoptosisSemantic proximity Read ↗

Deep RNA Sequencing Reveals a Repertoire of Human Fibroblast Circular RNAs Associated with Cellular Responses to Herpes Simplex Virus 1 InfectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.