Article
Attenuated phenotypes and analysis of a herpes simplex virus 1 strain with partial deletion of the UL7, UL41 and LAT genes.
Virologica Sinica - 1 Oct 2017
Xu Xingli, Guo Yingqiu, Fan Shengtao, Cui Pingfang, Feng Min, Wang Lichun, Zhang Ying, Liao Yun, Zhang Xiaolong, Li Qihan
Abstract excerpt
We previously constructed a herpes simplex virus 1 (HSV-1) UL7 mutant virus (M1) and showed that a partial deletion mutation of the UL7 gene led to a lower proliferative rate and an attenuated phenotype. Using the M1 mutant, we further modified the UL41 gene, which encodes another tegument protein, and the latency-associated transcript (LAT) gene. Observations of the resulting mutants with modified UL7 and UL41...
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