Article
Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels.
Diabetologia - 1 Jun 2013
Baerenwald D A, Bonnefond A, Bouatia-Naji N, Flemming B P, Umunakwe O C, Oeser J K, Pound L D, Conley N L, Cauchi S, Lobbens S, Eury E, Balkau B, Lantieri O, Dadi P K, Jacobson D A, Froguel P, O'Brien R M
Abstract excerpt
AIMS/HYPOTHESIS: We previously identified the G6PC2 locus as a strong determinant of fasting plasma glucose (FPG) and showed that a common G6PC2 intronic single nucleotide polymorphism (SNP) (rs560887) and two common G6PC2 promoter SNPs (rs573225 and rs13431652) are highly associated with FPG. However, these promoter SNPs have complex effects on G6PC2 fusion gene expression, and our data suggested that only...
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