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Article

Susceptibility to type 2 diabetes may be modulated by haplotypes in G6PC2, a target of positive selection.

BMC evolutionary biology - 7 Feb 2017

Al-Daghri Nasser M, Pontremoli Chiara, Cagliani Rachele, Forni Diego, Alokail Majed S, Al-Attas Omar S, Sabico Shaun, Riva Stefania, Clerici Mario, Sironi Manuela

Abstract excerpt

BACKGROUND: The endoplasmic reticulum enzyme glucose-6-phosphatase catalyzes the common terminal reaction in the gluconeogenic/glycogenolytic pathways and plays a central role in glucose homeostasis. In most mammals, different G6PC subunits are encoded by three paralogous genes (G6PC, G6PC2, and G6PC3). Mutations in G6PC and G6PC3 are responsible for human mendelian diseases, whereas variants in G6PC2 are...

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Identifiers

PMID: 28173748
DOI: 10.1186/s12862-017-0897-z
PMCID: PMC5297017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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