Article
Did circular DNA shape the evolution of mammalian genomes?
2022-06-24
Abstract excerpt
Extrachromosomal circular DNA of chromosomal origin (eccDNA) can rapidly shape the evolution and adaptation of mitotically dividing cells such as tumor cells. However, whether eccDNA has a permanent impact on genome evolution through the germline is largely unexplored. Here, we propose that a large fraction of the syntenic changes that are found between mammalian species are caused by germline transposition of ecc...
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Identifiers and source
- Literature Corpus work
- e03178d6-0084-5e95-886b-c328b281109d
- DOI
- 10.1101/2022.06.22.497135