Article
Circular DNA elements of chromosomal origin are common in healthy human somatic tissue.
Nature communications - 14 Mar 2018
Møller Henrik Devitt, Mohiyuddin Marghoob, Prada-Luengo Iñigo, Sailani M Reza, Halling Jens Frey, Plomgaard Peter, Maretty Lasse, Hansen Anders Johannes, Snyder Michael P, Pilegaard Henriette, Lam Hugo Y K, Regenberg Birgitte
Abstract excerpt
The human genome is generally organized into stable chromosomes, and only tumor cells are known to accumulate kilobase (kb)-sized extrachromosomal circular DNA elements (eccDNAs). However, it must be expected that kb eccDNAs exist in normal cells as a result of mutations. Here, we purify and sequence eccDNAs from muscle and blood samples from 16 healthy men, detecting ~100,000 unique eccDNA types from 16 million...
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