Article
The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene.
Cells - 5 Dec 2021
Garrido Jose Antonio Ma G, Alcantara Krizelle Mae M, Danac Joshua Miguel C, Serrano Fidel Emmanuel C, Cutiongco-de la Paz Eva Maria, Garcia Reynaldo L
Abstract excerpt
Phosphatase and tensin homolog deleted on chromosome 10, or PTEN, is a well-characterized tumor suppressor with both lipid and protein phosphatase activities. PTEN is often downregulated by epigenetic mechanisms such as hypermethylation, which leads to constitutive activation of the PI3K-Akt pathway. Large datasets from next-generation sequencing, however, revealed that mutations in PTEN may not only hamper...
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