Article
Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis.
PLoS pathogens - 1 Jun 2022
Johnson Bryan A, Zhou Yiyang, Lokugamage Kumari G, Vu Michelle N, Bopp Nathen, Crocquet-Valdes Patricia A, Kalveram Birte, Schindewolf Craig, Liu Yang, Scharton Dionna, Plante Jessica A, Xie Xuping, Aguilar Patricia, Weaver Scott C, Shi Pei-Yong, Walker David H, Routh Andrew L, Plante Kenneth S, Menachery Vineet D
Abstract excerpt
While SARS-CoV-2 continues to adapt for human infection and transmission, genetic variation outside of the spike gene remains largely unexplored. This study investigates a highly variable region at residues 203-205 in the SARS-CoV-2 nucleocapsid protein. Recreating a mutation found in the alpha and omicron variants in an early pandemic (WA-1) background, we find that the R203K+G204R mutation is sufficient to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.