Article

Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis

2021-10-15

Abstract excerpt

While SARS-CoV-2 continues to adapt for human infection and transmission, genetic variation outside of the spike gene remains largely unexplored. This study investigates a highly variable region at residues 203-205 in the SARS-CoV-2 nucleocapsid protein. Recreating a mutation found in the alpha and omicron variants in an early pandemic (WA-1) background, we find that the R203K+G204R mutation is sufficient to enhan...

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Literature Corpus work: de1ec489-24c6-5003-9370-0b52d3bf5547
DOI: 10.1101/2021.10.14.464390

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