Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.

doi:10.1016/j.cell.2020.06.043

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Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.

Cell - 20 Aug 2020

Korber Bette, Fischer Will M, Gnanakaran Sandrasegaram, Yoon Hyejin, Theiler James, Abfalterer Werner, Hengartner Nick, Giorgi Elena E, Bhattacharya Tanmoy, Foley Brian, Hastie Kathryn M, Parker Matthew D, Partridge David G, Evans Cariad M, Freeman Timothy M, de Silva Thushan I, McDanal Charlene, Perez Lautaro G, Tang Haili, Moon-Walker Alex, Whelan Sean P, LaBranche Celia C, Saphire Erica O, Montefiori David C

Abstract excerpt

A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies revealed a recurrent pattern of G614 increase at multiple geographic levels: national, regional, and municipal. The shift occurred even in local epidemics where the original D614 form was well established prior to introduction of the G614...

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Identifiers

PMID: 32697968
DOI: 10.1016/j.cell.2020.06.043
PMCID: PMC7332439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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