Article

SARS-CoV-2 Variants Evolve Convergent Strategies to Remodel the Host Response

2023-01-15

Abstract excerpt

More transmissible SARS-CoV-2 variants of concern (VOCs) emerged during the COVID-19 pandemic. Here, we used global proteomic and genomic approaches to study the host responses driving VOC evolution. We discovered VOCs evolved convergent strategies to remodel the host response by modulating viral RNA and protein levels, altering nucleocapsid phosphorylation, and rewiring virus-host protein-protein interactions. In...

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Literature Corpus work: d567f898-1264-51c1-b1dd-806bfcdf40d0
DOI: 10.2139/ssrn.4319535

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