Article
Association of the late cornified envelope-3 genes with psoriasis and psoriatic arthritis: a systematic review.
Journal of genetics and genomics = Yi chuan xue bao - 20 Feb 2015
Shen Changbing, Gao Jing, Yin Xianyong, Sheng Yujun, Sun Liangdan, Cui Yong, Zhang Xuejun
Abstract excerpt
Psoriasis (Ps) and psoriatic arthritis (PsA) are genetically complex diseases with strong genetic evidence. Recently, susceptibility genes for Ps and PsA have been identified within the late cornified envelop (LCE) gene cluster, especially the cluster 3 (LCE3) genes. It is noteworthy that the deletion of LCE3B and LCE3C (LCE3C_LCE3B-del) is significantly associated with these two diseases. Gene-gene interactions...
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