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Article

Variants in the Late Cornified Envelope Gene Locus Are Associated With Elevated T-helper 17 Responses in Patients With Postinfectious Lyme Arthritis.

The Journal of infectious diseases - 14 Aug 2024

Ehrbar Dylan, Arvikar Sheila L, Sulka Katherine B, Chiumento Geena, Nelson Nicole L J, Hernandez Sergio A, Williams Morgan A, Strle Franc, Steere Allen C, Strle Klemen

Abstract excerpt

BACKGROUND: Postinfectious Lyme arthritis (LA) is associated with dysregulated immunity and autoreactive T- and B-cell responses in joints. Here we explored the role of host genetic variation in this outcome. METHODS: The frequency of 253 702 single-nucleotide polymorphisms (SNPs) was determined in 147 patients with LA (87 with postinfectious LA and 60 with antibiotic-responsive LA), and for comparison in 90...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39140723
DOI: 10.1093/infdis/jiae164
PMCID: PMC11322884

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