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Article

Smc1β is required for activation of SAC during mouse oocyte meiosis

24 Jan 2017

Abstract excerpt

Smc1β is a meiosis-specific cohesin subunit that is essential for sister chromatid cohesion and DNA recombination. Previous studies have shown that Smc1β-deficient mice in both sexes are sterile. Ablation of Smc1β during male meiosis leads to the blockage of spermatogenesis in pachytene stage, and ablation of Smc1β during female meiosis generates a highly error-prone oocyte although it could develop to metaphase...

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PMID: 28118058
DOI: 10.1080/15384101.2017.1282583

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