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Article

Proton transfer pathway in anion channelrhodopsin-1.

eLife - 21 Dec 2021

Tsujimura Masaki, Kojima Keiichi, Kawanishi Shiho, Sudo Yuki, Ishikita Hiroshi

Abstract excerpt

Anion channelrhodopsin from Guillardia theta (GtACR1) has Asp234 (3.2 Å) and Glu68 (5.3 Å) near the protonated Schiff base. Here, we investigate mutant GtACR1s (e.g., E68Q/D234N) expressed in HEK293 cells. The influence of the acidic residues on the absorption wavelengths was also analyzed using a quantum mechanical/molecular mechanical approach. The calculated protonation pattern indicates that Asp234 is...

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Identifiers

PMID: 34930528
DOI: 10.7554/eLife.72264
PMCID: PMC8691836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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