Article
Possible mechanism of proton transfer through peptide groups in the H-pathway of the bovine cytochrome c oxidase.
Journal of the American Chemical Society - 8 Aug 2007
Kamiya Katsumasa, Boero Mauro, Tateno Masaru, Shiraishi Kenji, Oshiyama Atsushi
Abstract excerpt
The peptide group connecting Tyr440 and Ser441 of the bovine cytochrome c oxidase is involved in a recently proposed proton-transfer path (H-path) where, at variance with other pathways (D- and K-paths), a usual hydrogen-bond network is interrupted, thus making this proton propagation rather unconventional. Our density-functional based molecular dynamics simulations show that, despite this anomaly and provided...
Topics
- Amino Acids
- Animals
- Cattle
- Computer Simulation
- Electron Transport Complex IV
- Electrons
- Isomerism
- Models, Molecular
- Mutation
- Peptides
- Protein Structure, Quaternary
- Protein Structure, Tertiary
- Protein Subunits
- Protons