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Article

FunGraph: A statistical protocol to reconstruct omnigenic multilayer interactome networks for complex traits.

STAR protocols - 17 Dec 2021

Dong Ang, Feng Li, Yang Dengcheng, Wu Shuang, Zhao Jinshuai, Wang Jing, Wu Rongling

Abstract excerpt

We describe a statistical protocol of how to reconstruct and dissect functional omnigenic multilayer interactome networks that mediate complex dynamic traits in a genome-wide association study (GWAS). This protocol, named FunGraph, can analyze how each locus affects phenotypic variation through its own direct effect and a complete set of indirect effects due to regulation by other loci co-existing in large-scale...

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Identifiers

PMID: 34927094
DOI: 10.1016/j.xpro.2021.100985
PMCID: PMC8649398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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