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Article

A computational approach for identification of core modules from a co-expression network and GWAS data.

STAR protocols - 17 Sept 2021

Sabik Olivia L, Ackert-Bicknell Cheryl L, Farber Charles R

Abstract excerpt

This protocol describes the application of the "omnigenic" model of the genetic architecture of complex traits to identify novel "core" genes influencing a disease-associated phenotype. Core genes are hypothesized to directly regulate disease and may serve as therapeutic targets. This protocol leverages GWAS data, a co-expression network, and publicly available data, including the GTEx database and the...

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Identifiers

PMID: 34467232
DOI: 10.1016/j.xpro.2021.100768
PMCID: PMC8385446

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