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Article

Protocol for using GRPath to identify putative gene regulation paths in complex human diseases.

STAR protocols - 16 Dec 2022

Xi Xi, Li Haochen, Wei Lei, Zhang Xuegong

Abstract excerpt

Unfolding the "black-box" associations between genotype and phenotype is essential for understanding the molecular mechanisms of complex human diseases. Here, we describe the use of GRPath to uncover putative causal paths (pcPaths) from genetic variants to disease phenotypes. GRPath takes multiple omics data and summary statistics as input and identifies pcPaths that link the putative causal region (pcRegion),...

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Identifiers

PMID: 36386883
DOI: 10.1016/j.xpro.2022.101831
PMCID: PMC9664398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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