Article
Prevalence of deleterious ATM germline mutations in gastric cancer patients.
Oncotarget - 1 Dec 2015
Huang Dong-Sheng, Tao Hou-Quan, He Xu-Jun, Long Ming, Yu Sheng, Xia Ying-Jie, Wei Zhang, Xiong Zikai, Jones Sian, He Yiping, Yan Hai, Wang Xiaoyue
Abstract excerpt
Besides CDH1, few hereditary gastric cancer predisposition genes have been previously reported. In this study, we discovered two germline ATM mutations (p.Y1203fs and p.N1223S) in a Chinese family with a history of gastric cancer by screening 83 cancer susceptibility genes. Using a published exom...
Topics
- Adult
- Aged
- Ataxia Telangiectasia Mutated Proteins
- Base Sequence
- Family Health
- Gene Frequency
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Loss of Heterozygosity
- Male
- Middle Aged
- Molecular Sequence Data
- Pedigree
- Sequence Analysis, DNA