Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prevalence of deleterious ATM germline mutations in gastric cancer patients.

Oncotarget - 1 Dec 2015

Huang Dong-Sheng, Tao Hou-Quan, He Xu-Jun, Long Ming, Yu Sheng, Xia Ying-Jie, Wei Zhang, Xiong Zikai, Jones Sian, He Yiping, Yan Hai, Wang Xiaoyue

Abstract excerpt

Besides CDH1, few hereditary gastric cancer predisposition genes have been previously reported. In this study, we discovered two germline ATM mutations (p.Y1203fs and p.N1223S) in a Chinese family with a history of gastric cancer by screening 83 cancer susceptibility genes. Using a published exome sequencing dataset, we found deleterious germline mutations of ATM in 2.7% of 335 gastric cancer patients of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Base Sequence
Share to Family Health

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Predisposition to Disease

Share to Molecular Sequence Data

Share to Pedigree

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 26506520
DOI: 10.18632/oncotarget.5944
PMCID: PMC4747381

Genes

ATM
CDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevalence of deleterious ATM germline mutations in gastric cancer patients.PMID 26506520Read ↗

Germline likely pathogenic variants in ataxia-telangiectasia-mutated gene in an Iranian family with hereditary diffuse gastric cancer without CDH1 mutation.Semantic proximity Read ↗

Heterozygous Pathogenic Nonsense ATM Variant Resulting in Unusually High Gastric Cancer SusceptibilitySemantic proximity Read ↗

A multicenter study assessing the prevalence of germline genetic alterations in Chinese gastric cancer patientsSemantic proximity Read ↗

A multicenter study assessing the prevalence of germline genetic alterations in Chinese gastric cancer patientsSemantic proximity Read ↗

Genetic Gastric Cancer Susceptibility in the International Clinical Cancer Genomics Community Research Network.Semantic proximity Read ↗

Profiling of the genetic features of Chinese patients with gastric cancer with HRD germline mutations in a large-scale retrospective study.Semantic proximity Read ↗

Whole-Exome Sequencing Among Chinese Patients With Hereditary Diffuse Gastric Cancer.Semantic proximity Read ↗

Prevalence of Pathogenic Germline Variants in Patients With Gastric Cancer Ascertained Through Multigene Panel TestingSemantic proximity Read ↗

The role of multi-organ cancer predisposition genes in the risk of inherited and histologically diverse gastric cancer.Semantic proximity Read ↗

Disease spectrum of gastric cancer susceptibility genes.Semantic proximity Read ↗

Molecular profiles and mutation burden analysis in Chinese patients with gastric carcinomaSemantic proximity Read ↗

[Next-Generation Sequencing-Based Detection of Gene Mutations and Its Association With Clinicopathological Features in Gastric Cancer].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.