Article
Generation of Tumor Targeted Dendritic Cell Vaccines with Improved Immunogenic and Migratory Phenotype.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022
Swartz Adam M, Hotchkiss Kelly M, Nair Smita K, Sampson John H, Batich Kristen A
Abstract excerpt
Our group has employed methodologies for effective ex vivo generation of dendritic cell (DC) vaccines for patients with primary malignant brain tumors. In order to reliably produce the most potent, most representational vaccinated DC that will engender an antitumor response requires the ability to orchestrate multiple methodologies that address antigen cross-presentation, T-cell costimulation and polarization,...
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