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Article

Different In Vitro-Generated MUTZ-3-Derived Dendritic Cell Types Secrete Dexosomes with Distinct Phenotypes and Antigen Presentation Potencies.

International journal of molecular sciences - 28 Jul 2022

Sakamoto Takuya, Koya Terutsugu, Togi Misa, Yoshida Kenichi, Kato Tomohisa, Ishigaki Yasuhito, Shimodaira Shigetaka

Abstract excerpt

Human dendritic cell (DC) dexosomes were evaluated for their function and preclinical validation for vaccines. Dexosomes are small DC-secreted vesicles that contain absorbing immune signals. Vaccine manufacturing requires a significant number of monocyte-derived DCs (Mo-DCs) from donor blood; thus, Mo-DC dexosomes are expected to serve as novel materials for cancer vaccination. In this study, we characterized a...

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Identifiers

PMID: 35955496
DOI: 10.3390/ijms23158362
PMCID: PMC9368791

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