Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice.

doi:10.1016/j.xcrm.2021.100455

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Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice.

Cell reports. Medicine - 21 Dec 2021

Abusarah Jamilah, Khodayarian Fatemeh, El-Hachem Nehme, Salame Natasha, Olivier Martin, Balood Mohammad, Roversi Katiane, Talbot Sebastien, Bikorimana Jean-Pierre, Chen Jingkui, Jolicoeur Mario, Trudeau Louis-Eric, Kamyabiazar Samaneh, Annabi Borhane, Robert Francis, Pelletier Jerry, El-Kadiry Abed-El-Hakim, Shammaa Riam, Rafei Moutih

Abstract excerpt

Dendritic cells (DCs) excel at cross-presenting antigens, but their effectiveness as cancer vaccine is limited. Here, we describe a vaccination approach using mesenchymal stromal cells (MSCs) engineered to express the immunoproteasome complex (MSC-IPr). Such modification instills efficient antigen cross-presentation abilities associated with enhanced major histocompatibility complex class I and CD80 expression,...

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Identifiers

PMID: 35028603
DOI: 10.1016/j.xcrm.2021.100455
PMCID: PMC8714858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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