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Article

Epigenetic loss of heterogeneity from low to high grade localized prostate tumours

15 Dec 2021

Abstract excerpt

Identifying precise molecular subtypes attributable to specific stages of localized prostate cancer has proven difficult due to high levels of heterogeneity. Bulk assays represent a population-average, which mask the heterogeneity that exists at the single-cell level. In this work, we sequence the accessible chromatin regions of 14,424 single-cells from 18 flash-frozen prostate tumours. We observe shared...

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PMID: 34911933
DOI: 10.1038/s41467-021-27615-8

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