Article
"Aerobic glycolytic imaging" of human gliomas using combined pH-, oxygen-, and perfusion-weighted magnetic resonance imaging.
NeuroImage. Clinical - 1 Jan 2021
Hagiwara Akifumi, Yao Jingwen, Raymond Catalina, Cho Nicholas S, Everson Richard, Patel Kunal, Morrow Danielle H, Desousa Brandon R, Mareninov Sergey, Chun Saewon, Nathanson David A, Yong William H, Andrei Gafita, Divakaruni Ajit S, Salamon Noriko, Pope Whitney B, Nghiemphu Phioanh L, Liau Linda M, Cloughesy Timothy F, Ellingson Benjamin M
Abstract excerpt
PURPOSE: To quantify abnormal metabolism of diffuse gliomas using "aerobic glycolytic imaging" and investigate its biological correlation. METHODS: All subjects underwent a pH-weighted amine chemical exchange saturation transfer spin-and-gradient-echo echoplanar imaging (CEST-SAGE-EPI) and dynamic susceptibility contrast perfusion MRI. Relative oxygen extraction fraction (rOEF) was estimated as the ratio of...
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