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Article

Lower Lactate Levels and Lower Intracellular pH in Patients with IDH-Mutant versus Wild-Type Gliomas.

AJNR. American journal of neuroradiology - 1 Aug 2020

Wenger K J, Steinbach J P, Bähr O, Pilatus U, Hattingen E

Abstract excerpt

BACKGROUND AND PURPOSE: Preclinical evidence points toward a metabolic reprogramming in isocitrate dehydrogenase (IDH) mutated tumor cells with down-regulation of the expression of genes that encode for glycolytic metabolism. We noninvasively investigated lactate and Cr concentrations, as well as intracellular pH using 1H/phosphorus 31 (31P) MR spectroscopy in a cohort of patients with gliomas. MATERIALS AND...

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Identifiers

PMID: 32646946
DOI: 10.3174/ajnr.A6633
PMCID: PMC7658891

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