Article
Visualization of tumor heterogeneity and prediction of isocitrate dehydrogenase mutation status for human gliomas using multiparametric physiologic and metabolic MRI.
Scientific reports - 20 Jan 2022
Hagiwara Akifumi, Tatekawa Hiroyuki, Yao Jingwen, Raymond Catalina, Everson Richard, Patel Kunal, Mareninov Sergey, Yong William H, Salamon Noriko, Pope Whitney B, Nghiemphu Phioanh L, Liau Linda M, Cloughesy Timothy F, Ellingson Benjamin M
Abstract excerpt
This study aimed to differentiate isocitrate dehydrogenase (IDH) mutation status with the voxel-wise clustering method of multiparametric magnetic resonance imaging (MRI) and to discover biological underpinnings of the clusters. A total of 69 patients with treatment-naïve diffuse glioma were scanned with pH-sensitive amine chemical exchange saturation transfer MRI, diffusion-weighted imaging, fluid-attenuated...
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