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Article

Molecular subtyping and POLE mutation spectrum in endometrial carcinoma.

The Indian journal of medical research - 1 Sept 2026

Uppin Megha, Thomas Derin Mary, Shantappa Rajshekhar, Konatam Meher Lakshmi, Ratnagiri Ranganath, Puranum Kaushik, Razzak Khalid, Uppin Shantveer G

Abstract excerpt

Background and objectives Endometrial carcinoma is the most common gynaecological malignancy and an emerging global health concern with limited molecular data from Indian cohorts. Our study investigated the molecular subtypes and POLE gene mutation spectrum in the South Indian cohort. Methods Molecular subtyping was carried out using ProMisE classification, categorising patients into four molecular subgroups....

Read the complete abstract on PubMed

Topics

Humans
Female
DNA Polymerase II
Endometrial Neoplasms
Poly-ADP-Ribose Binding Proteins
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

DNA Mismatch Repair

Tumor Suppressor Protein p53

Aged

India

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 42690860
DOI: 10.25259/IJMR_2714_2025
PMCID: PMC13541202

Genes

POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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