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Article

Validation of Modaplex POLE mutation assay in endometrial carcinoma.

Virchows Archiv : an international journal of pathology - 1 Dec 2023

Dorca Eduard, Velasco Ana, Varela Mar, Gatius Sonia, Villatoro Sergio, Fullana Neus, Cuevas Dolors, Vaquero Marta, Birnbaum Astrid, Neumann Karsten, Matias-Guiu Xavier

Abstract excerpt

The TCGA-based molecular classification of endometrial cancer has emerged as an important tool to stratify patients according to prognosis. A simplified scheme has been proposed, by using immunohistochemistry for p53, MSH6, and PMS2 and a molecular test for POLE mutations (NGS or Sanger sequencing, techniques that are not available in many centers worldwide). In this study, we validate a novel method that allows...

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Identifiers

PMID: 37874375
DOI: 10.1007/s00428-023-03636-0
PMCID: PMC10700217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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