Article
Comprehensive characteristics of pathological subtypes in testicular germ cell tumor: Gene expression, mutation and alternative splicing.
Frontiers in immunology - 1 Jan 2022
Yao Xiangyang, Zhou Hui, Duan Chen, Wu Xiaoliang, Li Bo, Liu Haoran, Zhang Yangjun
Abstract excerpt
Background: Testicular germ cell tumor (TGCT) is the most common tumor in young men, but molecular signatures, especially the alternative splicing (AS) between its subtypes have not yet been explored. Methods: To investigate the differences between TGCT subtypes, we comprehensively analyzed the data of gene expression, alternative splicing (AS), and somatic mutation in TGCT patients from the TCGA database. The...
Topics
- Testicular Neoplasms
- Alternative Splicing
- Humans
- Male
- Gene Expression
- DNA, Recombinant
- Seminoma
- Neoplasms, Germ Cell and Embryonal
- Mutation
- Carcinoma, Embryonal